Design, synthesis, anticancer and in silico assessment of 8-piperazinyl caffeinyl-triazolylmethyl hybrid conjugates

Author:

Soltani Rad Mohammad Navid12ORCID,Behrouz Somayeh12ORCID,Shahbazkhani Kiana1ORCID,Behrouz Marzieh1,Zarenezhad Elham3ORCID,Ghanbariasad Ali4

Affiliation:

1. Department of Chemistry, Shiraz University of Technology, Shiraz 71555-313, Iran

2. Medicinal Chemistry Research Laboratory, Novel Technology for Health Research Center, Shiraz University of Technology, Shiraz 71555-313, Iran

3. Non-communicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran

4. Department of Medical Biotechnology, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran

Abstract

Design, synthesis, anticancer, docking, and in silico assessment for 8-piperazinyl caffeinyl-triazolylmethyl hybrid conjugates are explained. These compounds have satisfactory activities against melanoma and breast cancer cell lines.

Funder

Shiraz University of Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Reference54 articles.

1. Global burden of cancer attributable to infections in 2018: a worldwide incidence analysis

2. https://www.who.int/news-room/fact-sheets/detail/cancer , accessed 1 July 2023

3. https://www.who.int/news-room/fact-sheets/detail/breast-cancer , accessed 1 July 2023

4. Breast Cancer—Epidemiology, Risk Factors, Classification, Prognostic Markers, and Current Treatment Strategies—An Updated Review

5. Melanoma therapeutics: a literature review

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