C(sp3)–H dehydrogenation and C(sp2)–H alkoxy carbonylation of inactivated cyclic amines towards functionalized N-heterocycles-Reference-Cited by-同舟云学术

C(sp3)–H dehydrogenation and C(sp2)–H alkoxy carbonylation of inactivated cyclic amines towards functionalized N-heterocycles

Published:2017 Issue:28 Volume:53 Page:4002-4005
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

He Yan¹²³⁴⁵,Wang Fang¹²³⁴⁵,Zhang Xinying¹²³⁴⁵,Fan Xuesen¹²³⁴⁵^ORCID

Affiliation:

1. School of Chemistry and Chemical Engineering

2. School of Environment

3. Collaborative Innovation Centre of Henan Province for Green Manufacturing of Fine Chemicals

4. Henan Key Laboratory of Organic Functional Molecule and Drug Innovation

5. Henan Normal University

Abstract

A novel and efficient synthesis of tetrahydropyridine-, dihydropyrrole-, and tetrahydroazepine-3-carboxylates via cascade reactions of cyclic amines with CO and alcohols is presented. To our knowledge, this should be the first example in which functionalized N-heterocycles were prepared through Pd-catalyzed C(sp³)–H dehydrogenation and C(sp²)–H carbonylation of cyclic amines.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2017/CC/C6CC10227A

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4. Organocatalyzed highly atom economic one pot synthesis of tetrahydropyridines as antimalarials

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