Transgenic PDGF-BB/sericin hydrogel supports for cell proliferation and osteogenic differentiation

Author:

Wang Feng12345ORCID,Hou Kai12345,Chen Wenjing12345,Wang Yuancheng12345,Wang Riyuan12345,Tian Chi12345,Xu Sheng12345,Ji Yanting12345,Yang Qianqian12345,Zhao Ping12345,Yu Ling67458ORCID,Lu Zhisong67458ORCID,Zhang Huijie91058,Li Fushu11121058,Wang Han11121058,He Baicheng11121058,Kaplan David L.13141516ORCID,Xia Qingyou12345

Affiliation:

1. Biological Science Research Center

2. Chongqing Key Laboratory of Sericultural Science

3. Chongqing Engineering and Technology Research Center for Novel Silk Materials

4. Southwest University

5. Chongqing

6. Institute for Clean Energy & Advanced Materials

7. Faculty of Materials & Energy

8. People's Republic of China

9. Key Laboratory of Biochemistry and Molecular Pharmacology of Chongqing

10. Chongqing Medical University

11. Department of Pharmacology

12. School of Pharmacy

13. Department of Biomedical Engineering

14. Tufts University

15. Medford

16. USA

Abstract

The present study demonstrates fabrication of PDGF-BB functionalized sericin hydrogel to explore biomaterials-related utility in bone tissue engineering.

Funder

National Natural Science Foundation of China

National Basic Research Program of China

Chongqing Science and Technology Commission

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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