Poly(lactic acid)-hyperbranched polyglycerol nanoparticles enhance bioadhesive treatment of esophageal disease and reduce systemic drug exposure-Reference-Cited by-同舟云学术

Poly(lactic acid)-hyperbranched polyglycerol nanoparticles enhance bioadhesive treatment of esophageal disease and reduce systemic drug exposure

Published:2022 Issue:23 Volume:14 Page:8418-8428
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Mai Yang¹,Ouyang Yaqi¹,Qin Yujia¹,Jia Changchang²,McCoubrey Laura E.³,Basit Abdul W.³,Nie Yichu⁴,Jia Yizhen¹,Yu Liu¹,Dou Liu¹,Deng Wenbin¹,Deng Yang¹,Liu Yang¹^ORCID

Affiliation:

1. School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Guangzhou, 510275, China

2. Cell-Gene Therapy Translational Medicine Research Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510000, China

3. UCL School of Pharmacy, University College London, 29–39 Brunswick Square, London, WC1N 1AX, UK

4. Clinical Research Institute, The First People's Hospital of Foshan & Sun Yat-sen University Foshan Hospital, Foshan, 528000, China

Abstract

Bioadhesive nanoparticles were developed for local drug delivery to esophagus, which elongated drug release time and enhanced esophageal drug exposure, providing significant therapeutic efficacy on achalasia.

Funder

National Natural Science Foundation of China

Shenzhen Science and Technology Innovation Program

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NR/D2NR01846B

Reference33 articles.

1. National Cancer Institute , Cancer Stat Facts: Esophageal Cancer , 2021 . https://seer.cancer.gov/statfacts/html/esoph.html . Accessed 4 March 2022

2. Advances in targeted therapy for esophageal cancer

3. Epidemiologic and Economic Burden of Achalasia in the United States

4. The Changing Epidemiology of Gastroesophageal Reflux Disease: Are Patients Getting Younger?

5. Natural history of eosinophilic esophagitis: a systematic review of epidemiology and disease course

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