Catalytic asymmetric synthesis of 2,5-dihydrofurans using synergistic bifunctional Ag catalysis

Author:

Shi Taoda12345,Teng Shenghan12345,Gopi Krishna Reddy Alavala6785,Guo Xin69105,Zhang Yueteng1112131415,Moore Kohlson T.1112131415,Buckley Thomas1112131415ORCID,Mason Damian J.1112131415,Wang Wei1112131415,Chapman Eli1112131415ORCID,Hu Wenhao6785

Affiliation:

1. Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development

2. School of Chemistry and Chemical Engineering

3. East China Normal University

4. Shanghai

5. China

6. School of Pharmaceutical Sciences

7. Sun Yat-sen University

8. Guangzhou

9. Wenzhou Medical University

10. Wenzhou

11. College of Pharmacy

12. Department of Pharmacology and Toxicology

13. the University of Arizona

14. Tucson

15. USA

Abstract

We report a bifunctional Ag catalyst promoted intramolecular capture of oxonium ylides with alkynes for the enantioselective synthesis of 2,5-dihydrofurans.

Funder

National Natural Science Foundation of China

University of Arizona

China Scholarship Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

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