Kinetic and inhibition studies on human Jumonji-C (JmjC) domain-containing protein 5-Reference-Cited by-同舟云学术

Kinetic and inhibition studies on human Jumonji-C (JmjC) domain-containing protein 5

Published:2023 Issue:6 Volume:4 Page:399-413
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Tumber Anthony¹,Salah Eidarus¹,Brewitz Lennart¹^ORCID,Corner Thomas P.¹,Schofield Christopher J.¹^ORCID

Affiliation:

1. Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield Road, OX1 3TA, Oxford, UK

Abstract

Robust mass spectrometry-based assays are reported which monitor catalysis of the 2-oxoglutarate-dependent oxygenase Jumonji-C domain-containing protein 5 (JMJD5). The assays have been applied to both kinetic and inhibition studies.

Funder

Wellcome Trust

Cancer Research UK

Biotechnology and Biological Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2023/CB/D2CB00249C

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