Novel 4-thiophenyl-pyrazole, pyridine, and pyrimidine derivatives as potential antitumor candidates targeting both EGFR and VEGFR-2; design, synthesis, biological evaluations, and<i>in silico</i>studies-Reference-Cited by-同舟云学术

Novel 4-thiophenyl-pyrazole, pyridine, and pyrimidine derivatives as potential antitumor candidates targeting both EGFR and VEGFR-2; design, synthesis, biological evaluations, andin silicostudies

Published:2023 Issue:18 Volume:13 Page:12184-12203
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Al-Muntaser Samia M.¹,Al-Karmalawy Ahmed A.²^ORCID,El-Naggar Abeer M.¹^ORCID,Ali Ali Khalil¹^ORCID,Abd El-Sattar Nour E. A.¹^ORCID,Abbass Eslam M.¹^ORCID

Affiliation:

1. Department of Chemistry, Faculty of Science, Ain Shams University, Abbassiya 11566, Cairo, Egypt

2. Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, 6th of October City, Giza 12566, Egypt

Abstract

Novel 4-thiophenyl-pyrazole, pyridine, and pyrimidine derivatives as potential dual EGFR/VEGFR-2 inhibitors with promising antimicrobial activity as well.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RA/D3RA00416C

Reference59 articles.

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