Rationale design of novel substituted 1,3,5-triazine candidates as dual IDH1(R132H)/ IDH2(R140Q) inhibitors with high selectivity against acute myeloid leukemia: In vitro and in vivo preclinical investigations-Reference-Cited by-同舟云学术

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Rationale design of novel substituted 1,3,5-triazine candidates as dual IDH1(R132H)/ IDH2(R140Q) inhibitors with high selectivity against acute myeloid leukemia: In vitro and in vivo preclinical investigations

Published:2024-08 Issue: Volume:149 Page:107483
ISSN:0045-2068
Container-title:Bioorganic Chemistry
language:en
Short-container-title:Bioorganic Chemistry

Author:

Tawfik Haytham O.,Mousa Mai H.A.,Zaky Mohamed Y.,El-Dessouki Ahmed M.,Sharaky Marwa,Abdullah Omeima,El-Hamamsy Mervat H.,Al-Karmalawy Ahmed A.

Publisher

Elsevier BV

Reference73 articles.

1. Normal myeloid progenitor cell subset-associated gene signatures for acute myeloid leukaemia subtyping with prognostic impact;Schonherz;PLoS One,2020

2. Pathogenic mechanisms in acute myeloid leukemia;Chakraborty;Curr Treat Options Oncol,2022

3. N.C.I.A.o.h.s.c.g.s.-n.e. Surveillance Research Program.

4. Acute myeloid leukemia with IDH1 and IDH2 mutations: 2021 treatment algorithm;Issa;Blood Cancer J,2021

5. The potential for isocitrate dehydrogenase mutations to produce 2-hydroxyglutarate depends on allele specificity and subcellular compartmentalization;Ward;J Biol Chem,2013

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