Practical and sustainable preparation of pyrrolo[2,3-<i>b</i>]indoles by Cu/Fe catalyzed intramolecular C(sp<sup>2</sup>)

Practical and sustainable preparation of pyrrolo[2,3-b]indoles by Cu/Fe catalyzed intramolecular C(sp²)–H amination

Published:2022 Issue:19 Volume:24 Page:7340-7345
ISSN:1463-9262
Container-title:Green Chemistry
language:en
Short-container-title:Green Chem.

Author:

Corrieri Matteo¹^ORCID,Crescentini Lucia De¹^ORCID,Mantellini Fabio¹^ORCID,Mari Giacomo¹^ORCID,Santeusanio Stefania¹^ORCID,Favi Gianfranco¹^ORCID

Affiliation:

1. Department of Biomolecular Sciences, Section of Chemistry and Pharmaceutical Technologies, University of Urbino “Carlo Bo”, Via I Maggetti 24, 61029 Urbino, Italy

Abstract

The direct synthesis of pyrrolo[2,3-b]indoles is developed using a Cu/Fe cocatalyzed intramolecular cycloamination of α-indolylhydrazones. This transformation proceeds cleanly and selectively at 50 °C in air, with water as the only reaction medium.

Funder

Università degli Studi di Urbino Carlo Bo

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/GC/D2GC02340G

Reference93 articles.

1. Renaissance of Ullmann and Goldberg Reactions - Progress in Copper Catalyzed C-N-, C-O- and C-S-Coupling

2. Modern Synthetic Methods for Copper-Mediated C(aryl)O, C(aryl)N, and C(aryl)S Bond Formation

3. Copper catalysed Ullmann type chemistry: from mechanistic aspects to modern development