Addition of nitrogen dioxide to carbon–carbon double bond followed by a cyclization to construct nitromethylated isoquinolinediones

Author:

Li Xuanxuan1234,Zhuang Shengyi1234,Fang Xinxin1234,Liu Ping1234,Sun Peipei1234ORCID

Affiliation:

1. College of Chemistry and Materials Science

2. Nanjing Normal University; Jiangsu Provincial Key Laboratory of Material Cycle Processes and Pollution Control; Jiangsu Collaborative Innovation Center of Biomedical Functional Materials

3. Nanjing 210023

4. China

Abstract

4-(Nitromethyl)isoquinoline-1,3(2H,4H)-diones were synthesized via a tandem nitration/cyclization reaction of N-alkyl-N-methacryloyl benzamides using CO2 as the nitro source.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference45 articles.

1. Naturally-occurring nitro compounds

2. H. Feuer and A. T.Nielson, Nitro Compounds: Recent Advances in Synthesis and Chemistry, VCH, Weinheim, 1990

3. N. Ono , The Nitro Group in Organic Synthesis, Wiley-VCH, Weinheim, 2001

4. Nitro and related compounds

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