Repurposed organoselenium tethered amidic acids as apoptosis inducers in melanoma cancer via P53, BAX, caspases-3, 6, 8, 9, BCL-2, MMP2, and MMP9 modulations

Author:

Shaaban Saad12ORCID,Althikrallah Hanan A.1ORCID,Negm Amr1ORCID,Abo Elmaaty Ayman3,Al-Karmalawy Ahmed A.45ORCID

Affiliation:

1. Department of Chemistry, College of Science, King Faisal University, Al-Ahsa 31982, Saudi Arabia

2. Department of Chemistry, Faculty of Science, Mansoura University, 35516 Mansoura, Egypt

3. Medicinal Chemistry Department, Faculty of Pharmacy, Port Said University, Port Said, 42511, Egypt

4. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Horus University–Egypt, New Damietta 34518, Egypt

5. Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, 6th of October City, Giza 12566, Egypt

Abstract

Repurposed organoselenium tethered amidic acids as apoptosis inducers in melanoma.

Funder

Ministry of Education – Kingdom of Saudi Arabi

Publisher

Royal Society of Chemistry (RSC)

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