Lead Optimization of BIBR1591 To Improve Its Telomerase Inhibitory Activity: Design and Synthesis of Novel Four Chemical Series with In Silico, In Vitro, and In Vivo Preclinical Assessments-Reference-Cited by-同舟云学术

Lead Optimization of BIBR1591 To Improve Its Telomerase Inhibitory Activity: Design and Synthesis of Novel Four Chemical Series with In Silico, In Vitro, and In Vivo Preclinical Assessments

Published:2023-12-20 Issue:1 Volume:67 Page:492-512
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Al-Karmalawy Ahmed A.¹²^ORCID,Mousa Mai H. A.³,Sharaky Marwa⁴,Mourad Mai A. E.⁵,El-Dessouki Ahmed M.⁶,Hamouda Amir O.⁷,Alnajjar Radwan⁸⁹,Ayed Abdelmoneim A.¹⁰,Shaldam Moataz A.¹¹^ORCID,Tawfik Haytham O.¹²^ORCID

Affiliation:

1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Horus University-Egypt, New Damietta 34518, Egypt

2. Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, 6h of October City, Giza 12566, Egypt

3. Pharmaceutical Chemistry Department, Faculty of Pharmacy and Drug Technology, Egyptian Chinese University, Cairo 11786, Egypt

4. Cancer Biology Department, Pharmacology Unit, National Cancer Institute (NCI), Cairo University, Cairo 12613, Egypt

5. Medicinal Chemistry Department, Faculty of Pharmacy, Port-Said University, Port-Said 42511, Egypt

6. Pharmacology and Toxicology Department, Faculty of Pharmacy, Ahram Canadian University, 6th of October City, Giza 12566, Egypt

7. Department of Biochemistry, Faculty of Pharmacy, Horus University-Egypt, New Damietta 34518, Egypt

8. Department of Chemistry, Faculty of Science, University of Benghazi, Benghazi 1308, Libya

9. PharmD, Faculty of Pharmacy, Libyan International Medical University, Benghazi 1308, Libya

10. Department of Chemistry, Faculty of Science, Tanta University, Tanta 31527, Egypt

11. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh 33516, Egypt

12. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta 31527, Egypt

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01708

Reference85 articles.

1. Association of the COVID-19 Pandemic With Patterns of Statewide Cancer Services

2. Cancer statistics, 2023

3. Fundamental mechanisms of telomerase action in yeasts and mammals: understanding telomeres and telomerase in cancer cells

4. Dihydropyrazole derivatives as telomerase inhibitors: Structure-based design, synthesis, SAR and anticancer evaluation in vitro and in vivo

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