Extending the <i>in vivo</i> persistence of synthetic glycoconjugates using a serum-protein binder-Reference-Cited by-同舟云学术

Extending the in vivo persistence of synthetic glycoconjugates using a serum-protein binder

Published:2022 Issue:10 Volume:3 Page:1260-1275
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Daskhan Gour Chand¹^ORCID,Motyka Bruce²³^ORCID,Bascom Roger²³^ORCID,Tran Hanh Thuc¹^ORCID,Tao Kesheng²³^ORCID,West Lori J.²³⁴^ORCID,Cairo Christopher W.¹³^ORCID

Affiliation:

1. Department of Chemistry, University of Alberta, Edmonton, Alberta, T6G 2G2, Canada

2. Department of Pediatrics, Alberta Transplant Institute, University of Alberta, Edmonton, Alberta, T6G 2E1, Canada

3. Canadian Donation and Transplantation Research Program, University of Alberta, Edmonton, Alberta, T6G 2E1, Canada

4. Departments of Surgery, Medical Microbiology & Immunology, and Laboratory Medicine & Pathology, University of Alberta, Edmonton, Alberta, T6G 2E1, Canada

Abstract

A strategy for augmenting multivalent glycoconjugates with a serum-protein recognition element extends half-life in vivo and maintains engagement with lectin receptors.

Funder

Alberta Glycomics Centre

Natural Sciences and Engineering Research Council of Canada

Publisher

Royal Society of Chemistry (RSC)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CB/D2CB00126H

Reference33 articles.

1. Multivalent glycoconjugate syntheses and applications using aromatic scaffolds

2. Synthesis and medical applications of oligosaccharides

3. Multivalent ligand presentation as a central concept to study intricate carbohydrate–protein interactions

4. Design and Creativity in Synthesis of Multivalent Neoglycoconjugates

5. Synthetic Multivalent Ligands as Probes of Signal Transduction

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