Zn(ii)2,9-dimethyl-1,10-phenanthroline stimulates cultured bovine aortic endothelial cell proliferation

Author:

Nakamura Takehiro12345,Yoshida Eiko1234ORCID,Hara Takato1674,Fujie Tomoya1674,Yamamoto Chika1674,Fujiwara Yasuyuki89104ORCID,Ogata Fumihiko511124,Kawasaki Naohito511124,Takita Ryo1314154ORCID,Uchiyama Masanobu131415416ORCID,Kaji Toshiyuki1234ORCID

Affiliation:

1. Faculty of Pharmaceutical Sciences

2. Tokyo University of Science

3. Noda 278-8510

4. Japan

5. Faculty of Pharmacy

6. Toho University

7. Funabashi 274-8510

8. School of Pharmacy

9. Tokyo University of Pharmacy and Life Sciences

10. Hachioji 192-0392

11. Kindai University

12. Higashi-Osaka 577-8502

13. Graduate School of Pharmaceutical Sciences

14. The University of Tokyo

15. Bunkyo-ku 113-0033

16. Advanced Elements Chemistry Research Team

Abstract

Stimulation of vascular endothelial cell proliferation by Zn-12 can be mediated by the ERK1/2 activation independently of the FGF-2-FGFR pathway. Additionally, there may be other pathways involved in the Zn-12 stimulation.

Funder

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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