Open-air synthesis of oligo(ethylene glycol)-functionalized polypeptides from non-purified N-carboxyanhydrides

Author:

Tan Zhengzhong1234,Song Ziyuan1234ORCID,Xue Tianrui5234,Zheng Lining1234,Jiang Lei12346,Jiang Yunjiang1234ORCID,Fu Zihuan5234,Nguyen Anh7234,Leal Cecilia1234ORCID,Cheng Jianjun12345ORCID

Affiliation:

1. Department of Materials Science and Engineering

2. University of Illinois at Urbana-Champaign

3. Urbana

4. USA

5. Department of Chemistry

6. State Key Laboratory of Natural Medicines

7. Department of Chemical and Biomolecular Engineering

Abstract

We controllably polymerized non-purified OEG-NCAs using a biphasic SIMPLE polymerization strategy. The resulting OEG-functionalized amphiphilic copolypeptides could self-assemble into nanoparticles.

Funder

National Science Foundation

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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