Sustainable continuous flow synthesis of β-aminocarbonyls <i>via</i> acid-catalyzed hydration of <i>N</i>-Boc-2-azetines-Reference-Cited by-同舟云学术

Sustainable continuous flow synthesis of β-aminocarbonyls via acid-catalyzed hydration of N-Boc-2-azetines

Published:2023 Issue:12 Volume:8 Page:3203-3209
ISSN:2058-9883
Container-title:Reaction Chemistry & Engineering
language:en
Short-container-title:React. Chem. Eng.

Author:

Andresini Michael¹^ORCID,Colella Marco¹^ORCID,Dibenedetto Roberta Savina¹,Graziano Elena¹,Romanazzi Giuseppe²^ORCID,Aramini Andrea³^ORCID,Degennaro Leonardo¹^ORCID,Luisi Renzo¹^ORCID

Affiliation:

1. FLAME-Lab, Flow Chemistry and Microreactor Technology Laboratory Department of Pharmacy – Drug Sciences University of Bari “A. Moro”, Via E. Orabona 4 – 70125 Bari, Italy

2. DICATECh, Politecnico di Bari, Via E. Orabona, 4 – 70125 Bari, Italy

3. Department of Discovery, Dompé Farmaceutici S.p.A, Via Campo di Pile, L'Aquila I-67100, Italy

Abstract

In this work we report a waste-minimized continuous flow process for the synthesis of β-aminocarbonyls through hydration of N-Boc-2-azetines promoted under acid-catalysed conditions.

Funder

European Health and Digital Executive Agency

Publisher

Royal Society of Chemistry (RSC)

Subject

Fluid Flow and Transfer Processes,Process Chemistry and Technology,Chemical Engineering (miscellaneous),Chemistry (miscellaneous),Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RE/D3RE00342F

Reference34 articles.

1. The regioselective Wacker oxidation of internal allylamines: synthesis of functionalized and challenging β-amino ketones

2. Modern Variants of the Mannich Reaction

3. E. F.Kleinmann in Comprehensive Organic Synthesis , ed. B. M. Trost , I. Fleming and C. H. Heathcock , Pergamon , Oxford , 1991 , vol. 2 , p. 89

4. β-Peptidic Peptidomimetics

5. Highly efficient and enantioselective synthesis of β-heteroaryl amino alcohols via Ru-catalyzed asymmetric hydrogenation