Covalent and non-covalent albumin binding of Au(i) bis-NHCs via post-synthetic amide modification-Reference-Cited by-同舟云学术

Covalent and non-covalent albumin binding of Au(i) bis-NHCs via post-synthetic amide modification

Published:2021 Issue: Volume: Page:
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Sen Sajal¹²³⁴^ORCID,Perrin Mark W.¹²³⁴,Sedgwick Adam C.¹²³⁴^ORCID,Lynch Vincent M.¹²³⁴,Sessler Jonathan L.¹²³⁴^ORCID,Arambula Jonathan F.¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. The University of Texas at Austin

3. Austin

4. USA

Abstract

Au(i) bis-N-heterocyclic carbenes (NHCs) functionalized using an amide linker were found to bind to human serum albumin (HSA) in covalent and non-covalent fashion. The solubility and in vitro anti-cancer activity of these new conjugates were studied.

Funder

National Cancer Institute

Welch Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC01055G

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