In vivo deep-tissue microscopy with UCNP/Janus-dendrimers as imaging probes: resolution at depth and feasibility of ratiometric sensing-Reference-Cited by-同舟云学术

In vivo deep-tissue microscopy with UCNP/Janus-dendrimers as imaging probes: resolution at depth and feasibility of ratiometric sensing

Published:2020 Issue:4 Volume:12 Page:2657-2672
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Plunkett Shane¹²³⁴⁵,El Khatib Mirna¹²³⁴⁵,Şencan İkbal⁶⁷⁸⁹^ORCID,Porter Jason E.⁶⁷⁸⁹,Kumar Anand T. N.⁶⁷⁸⁹,Collins Joshua E.¹⁰¹¹¹²⁹,Sakadžić Sava⁶⁷⁸⁹,Vinogradov Sergei A.¹²³⁴⁵^ORCID

Affiliation:

1. Department of Biochemistry and Biophysics

2. Perelman School of Medicine

3. and Department of Chemistry

4. School of Arts and Sciences

5. University of Pennsylvania

6. Martinos Center for Biomedical Imaging

7. Massachusetts General Hospital/Harvard Medical School

8. Charlestown

9. USA

10. Intelligent Materials Solutions

11. Inc.

12. Princeton

Abstract

UCNP/Janus-dendrimers enable high-resolution two-photon imaging in the brain up to 1 mm-deep under low-power CW excitation. However, ratiometric sensing using UCNPs and excitation energy transfer is strongly obstructed by tissue absorption.

Funder

National Institute of Biomedical Imaging and Bioengineering

National Institute of Neurological Disorders and Stroke

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2020/NR/C9NR07778B

Reference119 articles.

1. Two-Photon Laser Scanning Fluorescence Microscopy

2. Deep tissue two-photon microscopy