Enantioselective total synthesis of pyrrolo-[2,1-c][1,4]-benzodiazepine monomers (S)-(−)-barmumycin and (S)-(+)-boseongazepine B
Author:
Affiliation:
1. Department of Chemistry
2. Savitribai Phule Pune University (Formerly University of Pune)
3. Pune 411007
4. India
Abstract
An efficient enantioselective total synthesis of pyrrolo-[2,1-c][1,4]benzodiazepine (PBD) monomers (S)-(−)-barmumycin and (S)-(+)-boseongazepine B was achieved through a stereocontrolled strategy, which relies on a proline catalysed asymmetric α-amination and ester α-ethylenation.
Funder
University Grants Committee
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2018/QO/C8QO00446C
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