Concise access to C2-ethylidene pyrrolo[1,4]benzodiazepine natural products-Reference-Cited by-同舟云学术

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Concise access to C2-ethylidene pyrrolo[1,4]benzodiazepine natural products

Published:2023 Issue:45 Volume:21 Page:9061-9064
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Leitis Zigmārs¹^ORCID,Sakaine Guna¹,Brokāne Katrīna¹,Smits Gints¹^ORCID

Affiliation:

1. Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga, LV-1006, Latvia

Abstract

The shortest total synthesis of three pyrrolo[1,4]benzodiazepine (PBD) antitumor antibiotic family natural products has been accomplished employing the Julia–Kocienski olefination as the key step.

Funder

European Regional Development Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D3OB01430D

Reference26 articles.

1. Isolation, chemistry, and biology of pyrrolo[1,4]benzodiazepine natural products

2. Synthesis of DNA-Interactive Pyrrolo[2,1-c][1,4]benzodiazepines (PBDs)

3. The development of pyrrolobenzodiazepines as antitumour agents

4. Synthesis of a novel C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione library: Effect of C2-aryl substitution on cytotoxicity and non-covalent DNA binding

5. From Anthramycin to Pyrrolobenzodiazepine (PBD)-Containing Antibody-Drug Conjugates (ADCs)

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