Development of on-DNA vinyl sulfone synthesis for DNA-encoded chemical libraries-Reference-Cited by-同舟云学术

Development of on-DNA vinyl sulfone synthesis for DNA-encoded chemical libraries

Published:2022 Issue:17 Volume:9 Page:4542-4548
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Gao Yuting¹^ORCID,Sun Yang¹^ORCID,Fang Xianfu¹^ORCID,Zhao Guixian¹^ORCID,Li Xufeng¹^ORCID,Zhang Gong¹²^ORCID,Li Yangfeng¹²^ORCID,Li Yizhou¹²³⁴^ORCID

Affiliation:

1. Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Innovative Drug Research Center, School of Pharmaceutical Sciences, Chongqing University, 401331 Chongqing, P. R. China

2. Chemical Biology Research Center, School of Pharmaceutical Sciences, Chongqing University, 401331 Chongqing, P. R. China

3. Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, 400044 Chongqing, P. R. China

4. Beijing National Laboratory for Molecular Sciences, 100190 Beijing, P. R. China

Abstract

We present the development of an efficient synthetic route to generate a DNA-compatible vinyl sulfone functional group, and the subsequent chemical transformations demonstrated the feasibility of our method in DEL construction.

Funder

Fundamental Research Funds for the Central Universities

Beijing National Laboratory for Molecular Sciences

Natural Science Foundation of Chongqing

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/QO/D2QO00881E

Reference71 articles.