Incorporation of viridicatin alkaloid-like scaffolds into DNA-encoded chemical libraries-Reference-Cited by-同舟云学术

Incorporation of viridicatin alkaloid-like scaffolds into DNA-encoded chemical libraries

Published:2023 Issue:10 Volume:21 Page:2162-2166
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Fang Xianfu¹^ORCID,Liao Huilin¹^ORCID,Fan Xiaohong¹²^ORCID,Wang Yiting¹^ORCID,Wang Huihong¹²^ORCID,Zhang Gong¹³^ORCID,Fang Wei²,Li Yangfeng¹³^ORCID,Li Yizhou¹³⁴⁵^ORCID

Affiliation:

1. Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Innovative Drug Research Center, School of Pharmaceutical Sciences, Chongqing University, 401331 Chongqing, P. R. China

2. Pharmaceutical Department of Chongqing Three Gorges Central Hospital, Chongqing University Three Gorges Hospital, 404100 Chongqing, P. R. China

3. Chemical Biology Research Center, School of Pharmaceutical Sciences, Chongqing University, 401331 Chongqing, P. R. China

4. Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, 400044 Chongqing, P. R. China

5. Beijing National Laboratory for Molecular Sciences, 100190 Beijing, P. R. China

Abstract

We have developed an efficient on-DNA synthesis of viridicatin alkaloid-like conjugates from isatins and DNA-tagged aldehydes.

Funder

Fundamental Research Funds for the Central Universities

Beijing National Laboratory for Molecular Sciences

National Natural Science Foundation of China

Natural Science Foundation of Chongqing

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry