Structural investigation on the electrostatic loop of native and mutated SOD1 and their interaction with therapeutic compounds-Reference-Cited by-同舟云学术

Structural investigation on the electrostatic loop of native and mutated SOD1 and their interaction with therapeutic compounds

Published:2015 Issue:44 Volume:5 Page:34630-34644
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Keerthana S. P.¹²³⁴,Kolandaivel P.¹²³⁴

Affiliation:

1. Department of Physics

2. Bharathiar University

3. Coimbatore

4. India-641 046

Abstract

The electrostatic loop of the native and mutated SOD1 protein with single point mutation in the loop is subjected to MD simulation. The structure and electrostatic properties of the native and mutated loops before/after interacting with small compounds are compared.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C5RA00286A

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4. Role of the electrostatic loop of Cu,Zn superoxide dismutase in the copper uptake process

5. Mechanical Probes of SOD1 Predict Systematic Trends in Metal and Dimer Affinity of ALS-Associated Mutants

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