Targeting mitochondrial degradation by chimeric autophagy-tethering compounds-Reference-Cited by-同舟云学术

Targeting mitochondrial degradation by chimeric autophagy-tethering compounds

Published:2023 Issue:40 Volume:14 Page:11192-11202
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Liu Zhenqi¹²,Qin Geng¹²,Yang Jie¹²,Wang Wenjie¹²,Zhang Wenting¹²,Lu Boxun³^ORCID,Ren Jinsong¹²^ORCID,Qu Xiaogang¹²^ORCID

Affiliation:

1. Laboratory of Chemical Biology, State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P. R. China

2. School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China

3. Neurology Department at Huashan Hospital, State Key Laboratory of Medical Neurobiology, Ministry of Education Frontiers Center for Brain Science, School of Life Sciences, Fudan University, Shanghai, China

Abstract

Inspired by receptor-mediated mitophagy, we develop a simple and versatile strategy to modulate mitophagy. Chimeric molecule mito-ATTECs can target mitochondria and interact directly with key autophagosome protein LC3 to trigger mitophagy.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC03600F

Reference46 articles.

1. Mechanisms of mitophagy in cellular homeostasis, physiology and pathology

2. Molecular mechanisms and physiological functions of mitophagy