Discovery of LLC355 as an Autophagy-Tethering Compound for the Degradation of Discoidin Domain Receptor 1

Author:

Liu Lianchao1,Zhao Lijie1,Yang Lujun23,Chai Minxue4,Liu Zhengyong5,Ma Nan5ORCID,Wang Yongxing6,Wu Qinxue1,Guo Jing5,Zhou Fengtao5ORCID,Huang Weixue1,Ren Xiaomei1,Wang Jian4ORCID,Ding Ming7,Wang Zhen1ORCID,Ding Ke135ORCID

Affiliation:

1. State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, #345 Lingling Road, Shanghai 200032, China

2. School of Molecular Medicine, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, #1 Xiangshan Branch Lane, Hangzhou 310024, China

3. Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China

4. College of Chemistry and Materials Science, Anhui Normal University, 189 South Jiuhua Road, Wuhu, Anhui 241002, China

5. International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Discovery of Chinese Ministry of Education (MOE), Guangzhou City Key Laboratory of Precision Chemical Drug Development, College of Pharmacy, Jinan University, 855 Xingye Avenue East, Guangzhou 511400, China

6. Livzon Research Institute, Livzon Pharmaceutical Group Inc., #38 Chuangye North Road, Jinwan District, Zhuhai 519000, China

7. School of Life Science and Technology, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211198, China

Funder

Shenzhen Bay Laboratory

Shanghai Key Laboratory of Chemical Biology

Science and Technology Commission of Shanghai Municipality

National Natural Science Foundation of China

Livzon Pharmaceutical Group Inc.

Publisher

American Chemical Society (ACS)

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