Photoswitchable anticancer activity via trans–cis isomerization of a combretastatin A-4 analog-Reference-Cited by-同舟云学术

Photoswitchable anticancer activity via trans–cis isomerization of a combretastatin A-4 analog

Published:2016 Issue:1 Volume:14 Page:40-49
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Sheldon Jonathon E.¹²³⁴⁵,Dcona M. Michael⁶²⁷⁴⁵,Lyons Charles E.⁵²⁸⁴,Hackett John C.⁹²⁷⁴⁵,Hartman Matthew C. T.¹²³⁴⁵

Affiliation:

1. Department of Chemistry

2. Virginia Commonwealth University

3. 1001 W. Main St., Richmond

4. USA

5. Massey Cancer Center

6. Department of Internal Medicine

7. 1101 E. Marshall St., Richmond

8. 401 College St., Richmond

9. Department of Physiology and Biophysics

Abstract

An azobenzene version of combretastatin A-4 is a highly potent anticancer drug that exhibits enhanced potency with light and automatic turn off of activity over time.

Funder

National Cancer Institute

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C5OB02005K

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