A photo-SAR study of photoswitchable azobenzene tubulin-inhibiting antimitotics identifying a general method for near-quantitative photocontrol-Reference-Cited by-同舟云学术

A photo-SAR study of photoswitchable azobenzene tubulin-inhibiting antimitotics identifying a general method for near-quantitative photocontrol

Published:2024 Issue:31 Volume:15 Page:12301-12309
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Reynders Martin¹,Garścia Małgorzata¹,Müller-Deku Adrian¹,Wranik Maximilian²,Krauskopf Kristina¹,de la Osa de la Rosa Luis¹,Schaffer Konstantin³⁴,Jötten Anna³⁴,Rode Alexander¹,Stierle Valentin³,Kraus Yvonne¹,Baumgartner Benedikt¹,Ali Ahmed¹,Bubeneck Andrei¹,Seal Trina¹,Steinmetz Michel O.²⁵,Paulitschke Philipp³⁴,Thorn-Seshold Oliver¹^ORCID

Affiliation:

1. Faculty of Chemistry and Pharmacy, Ludwig-Maximilians-University Munich, Munich 81377, Germany

2. Laboratory of Biomolecular Research, Division of Biology and Chemistry, Paul Scherrer Institut, Villigen 5232, Switzerland

3. Faculty of Physics and Center for NanoScience (CeNS), Ludwig-Maximilians-University Munich, Munich 80539, Germany

4. PHIO Scientific GmbH, Munich 81371, Germany

5. Biozentrum, University of Basel, Basel 4056, Switzerland

Abstract

We develop reagents to optically control microtubule dynamics, with (1) lensless microscopy to track their bioactivity; (2) photo-SAR to find GFP-compatible reagents; & (3) fluorophore antennas to drive single-photon isomerisation even ≥600 nm.

Funder

Deutsche Forschungsgemeinschaft

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Ludwig-Maximilians-Universität München

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D4SC03072A

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