Beyond the affinity for protein kinase C: exploring 2-phenyl-3-hydroxypropyl pivalate analogues as C1 domain-targeting ligands-Reference-Cited by-同舟云学术

Beyond the affinity for protein kinase C: exploring 2-phenyl-3-hydroxypropyl pivalate analogues as C1 domain-targeting ligands

Published:2015 Issue:4 Volume:6 Page:547-554
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Rossi Daniela¹²³⁴⁵,Talman Virpi⁶⁷⁸⁹,Gennäs Gustav Boije Af¹⁰⁷⁸⁹,Marra Annamaria¹²³⁴⁵,Picconi Pietro¹²³⁴⁵,Nasti Rita¹²³⁴⁵,Serra Massimo¹²³⁴⁵,Ann Jihyae¹¹¹²¹³¹⁴¹⁵,Amadio Marialaura¹¹⁶³¹⁷⁴,Pascale Alessia¹¹⁶³¹⁷⁴,Tuominen Raimo K.⁶⁷⁸⁹,Yli-Kauhaluoma Jari¹⁰⁷⁸⁹,Lee Jeewoo¹¹¹²¹³¹⁴¹⁵,Collina Simona¹²³⁴⁵

Affiliation:

1. Department of Drug Sciences

2. Medicinal Chemistry and Pharmaceutical Technology Section

3. University of Pavia

4. 27100 Pavia

5. Italy

6. Division of Pharmacology and Pharmacotherapy

7. Faculty of Pharmacy

8. University of Helsinki

9. Finland

10. Division of Pharmaceutical Chemistry and Technology

11. Laboratory of Medicinal Chemistry

12. College of Pharmacy

13. Seoul National University

14. Seoul 151-742

15. Korea

16. Pharmacology Section

17. Viale Taramelli 14

Abstract

Over the past fifteen years, we reported the design and synthesis of different series of compounds targeting the C1 domain of protein kinase C (PKC) that were based on various templates.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MD/C4MD00564C

Reference35 articles.

1. Protein Kinase C: Structural and Spatial Regulation by Phosphorylation, Cofactors, and Macromolecular Interactions

2. Happy birthday protein kinase C: Past, present and future of a superfamily

3. Protein Kinase C Contains a Pseudosubstrate Prototope in Its Regulatory Domain

4. Protein Kinase C: Structure, Function, and Regulation

5. Structural Basis of Protein Kinase C Isoform Function

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