Synthesis and biological evaluation of new aryl-alkyl(alkenyl)-4-benzylpiperidines, novel Sigma Receptor (SR) modulators, as potential anticancer-agents-Reference-Cited by-同舟云学术

Synthesis and biological evaluation of new aryl-alkyl(alkenyl)-4-benzylpiperidines, novel Sigma Receptor (SR) modulators, as potential anticancer-agents

Published:2016-11 Issue: Volume:124 Page:649-665
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Rui Marta,Rossi Daniela,Marra Annamaria,Paolillo Mayra^ORCID,Schinelli Sergio,Curti Daniela,Tesei Anna,Cortesi Michela,Zamagni Alice,Laurini Erik,Pricl Sabrina,Schepmann Dirk,Wűnsch Bernhard,Urban Ernst,Pace Vittorio,Collina Simona

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference75 articles.

1. Rat liver and kidney contain high densities of sigma 1 and sigma 2 receptors: characterization by ligand binding and photoaffinity labeling;Hellewell;Eur. J. Pharmacol.,1994

2. A proposal for the classification of sigma binding sites;Quirion;Trends Pharmacol. Sci.,1992

3. Purification, molecular cloning, and expression of the mammalian sigma1-binding site;Hanner;Proc. Natl. Acad. Sci. U.S.A.,1996

4. Sigma receptors: recent advances and new clinical potentials;Bowen;Pharm. Acta Helvetiae,2000

5. Sigma receptor modulators: a patent review;Collina;Exp. Opin. Ther. Pat.,2013

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