Novel pyrrole derivatives as selective CHK1 inhibitors: design, regioselective synthesis and molecular modeling-Reference-Cited by-同舟云学术

Novel pyrrole derivatives as selective CHK1 inhibitors: design, regioselective synthesis and molecular modeling

Published:2015 Issue:5 Volume:6 Page:852-859
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Eldebss Taha M. A.¹²³⁴⁵,Gomha Sobhi M.¹²³⁴⁵,Abdulla Mohamed M.⁶⁷⁵,Arafa Reem K.⁸⁹³¹⁰⁵

Affiliation:

1. Department of Chemistry

2. Faculty of Science

3. Cairo University

4. Giza 12613

5. Egypt

6. Research Unit, Saco Pharm. Co.

7. 6th October City

8. Pharmaceutical Chemistry Department

9. Faculty of Pharmacy

10. 11562 Giza

Abstract

3D binding interactions of 7a (magenta-colored carbons) and the co-crystallized ligand (cyan-colored carbons) with the active site amino acids of CHK1.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MD/C4MD00560K

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