Affiliation:
1. Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt
2. Department of Chemistry, Faculty of Applied Science, Umm Al-Qura University, Makkah Almukaramah, Saudi Arabia
Abstract
β-Amino-α,β-enones or β-enamino carbonyl compounds are versatile synthons intermediates for
the construction of various bio-active heterocyclic compounds and have been established as multipurpose synthetic
precursors in organic syntheses and in pharmaceutical developments. In this work, we will discuss the
different synthetic routes to obtain β−amino−α,β-enones or β-enamino carbonyl compounds, their reactions,
and their utility in the construction of organic frameworks and heterocyclic ring systems. Structurally, β-
amino-α,β-enones are attractive intermediates that syndicate the ambident behaviours of nucleophilicity and
electrophilicity of enones at the same time. β-amino-α,β-enones have been known as acceptors in both 1,2- and
1,4- additions that make them good intermediate compounds for annulation to different heterocycles.
Funder
Deanship of Scientific Research at Umm Al-Qura University, Saudi Arabia
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry,Biochemistry
Cited by
5 articles.
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