MOLPRINT 2D-based identification and synthesis of novel chromene based small molecules that target PLA2: validation through chemo- and bioinformatics approaches-Reference-Cited by-同舟云学术

MOLPRINT 2D-based identification and synthesis of novel chromene based small molecules that target PLA2: validation through chemo- and bioinformatics approaches

Published:2015 Issue:109 Volume:5 Page:89797-89808
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Keerthy Hosadurga K.¹²³⁴⁵,Vivek Hamse K.⁶⁷⁸⁹⁵,Bharathkumar Hanumantharayappa¹²³⁴⁵,Rangappa Shobith¹⁰¹¹¹²,Bulusu Krishna C.¹³²¹⁴¹⁵¹⁶,Mervin Lewis H.¹³²¹⁴¹⁵¹⁶,Fuchs Julian E.¹³²¹⁴¹⁵¹⁶,Priya Babu S.¹⁷¹⁸¹⁹⁵,Basappa Basappa¹²³⁴⁵,Swamy S Nanjuda⁶⁷⁸⁹⁵,Bender Andreas¹³²¹⁴¹⁵¹⁶,Rangappa Kanchugarakoppal S.¹⁷¹⁸¹⁹⁵

Affiliation:

1. Laboratory of Chemical Biology

2. Department of Chemistry

3. Bangalore University

4. Bangalore-560001

5. India

6. Department of Biotechnology

7. Sri Jayachamarajendra College of Engineering

8. JSS Technical Institutions Campus

9. Mysore

10. Frontier Research Centre for Post-genome Science and Technology

11. Hokkaido University

12. Japan

13. Centre for Molecular Informatics

14. University of Cambridge

15. Cambridge CB2 1EW

16. UK

17. Department of Studies in Chemistry

18. University of Mysore

19. Mysore-570 006

Abstract

A chemoinformatics approach identified 2-Amino-4-(2′-methyl-[1,1′-biphenyl]-4-yl)-5-oxo-4,5-dihydropyrano[3,2-c]chromene-3-carbonitrile as a snake venom PLA2 inhibitor, this was confirmed with an IC₅₀ = 12.5 μM.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C5RA13085A

Reference30 articles.

1. Phospholipase A2 structure/function, mechanism, and signaling

2. Phospholipase A2

3. Phospholipase A2 enzymes

4. Snake Venom Phospholipases A2: A Novel Tool Against Bacterial Diseases

5. Secretory phospholipase A2 induces dendritic cell maturation

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