Monomerization of Homodimeric Trefoil Factor 3 (TFF3) by an Aminonitrile Compound Inhibits TFF3-Dependent Cancer Cell Survival

Author:

Pandey Vijay1,Zhang Xi2ORCID,Poh Han-Ming3,Wang Baocheng1,Dukanya Dukanya4,Ma Lan12ORCID,Yin Zhinan56,Bender Andreas7ORCID,Periyasamy Ganga8ORCID,Zhu Tao910,Rangappa Kanchugarakoppal S.4,Basappa Basappa4ORCID,Lobie Peter E.123

Affiliation:

1. Tsinghua Berkeley Shenzhen Institute and Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Shenzhen 518055, PR China

2. Shenzhen Bay Laboratory, Shenzhen 518055, PR China

3. Cancer Science Institute of Singapore and Department of Pharmacology, National University of Singapore, Singapore 117599

4. Laboratory of Chemical Biology, Department of Studies in Organic Chemistry, University of Mysore, Manasagangotri, Mysore 570006 Karnataka, India

5. Biomedical Translational Research Institute, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, PR China

6. Zhuhai Institute of Translational Medicine Zhuhai People’s Hospital Affiliated with Jinan University, Jinan University, Zhuhai, Guangdong 519000, PR China

7. Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, United Kingdom

8. DOS in Chemistry, Bangalore University, JB Campus, Bangalore 560001, India

9. Department of Oncology of the First Affiliated Hospital, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230027, China

10. Hefei National Laboratory for Physical Sciences, the CAS Key Laboratory of Innate Immunity and Chronic Disease, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230027, China

Funder

Shenzhen Bay Laboratory

National Medical Research Council

Ministry of Education - Singapore

Department of Biotechnology , Ministry of Science and Technology

National Research Foundation Singapore

Science, Technology and Innovation Commission of Shenzhen Municipality

Vision Group on Science and Technology

Tsinghua-Berkeley Center

National Natural Science Foundation of China

National University Cancer Institute, Singapore

Tsinghua Shenzhen International Graduate School

Shenzhen Development and Reform Commission Subject Construction Project

Guangdong Basic and Applied Basic Research Foundation

Universities Stable Funding Key Projects

Publisher

American Chemical Society (ACS)

Subject

Pharmacology (medical),Pharmacology

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