Perturbation of liquid droplets of P-granule protein LAF-1 by the antimicrobial peptide LL-III-Reference-Cited by-同舟云学术

Perturbation of liquid droplets of P-granule protein LAF-1 by the antimicrobial peptide LL-III

Published:2020 Issue:78 Volume:56 Page:11577-11580
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Oliva Rosario¹²³⁴⁵,Mukherjee Sanjib K.¹²³⁴⁵,Fetahaj Zamira¹²³⁴⁵,Möbitz Simone¹²³⁴⁵,Winter Roland¹²³⁴⁵^ORCID

Affiliation:

1. Physical Chemistry I - Biophysical Chemistry

2. Faculty of Chemistry and Chemical Biology

3. TU Dortmund University

4. D-44227 Dortmund

5. Germany

Abstract

Protein/RNA droplet formation by liquid–liquid phase separation has emerged as a key mechanism for cellular organization. We show that binding of antimicrobial peptides such as LL-III can lead to loss of droplet function.

Funder

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CC/D0CC04877A

Reference22 articles.

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3. Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates

4. Liquid–Liquid Phase Separation in Disease

5. Biomolecular condensates: organizers of cellular biochemistry

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