Synthesis, biological evaluation and molecular modeling of urea-containing MraY inhibitors-Reference-Cited by-同舟云学术

Synthesis, biological evaluation and molecular modeling of urea-containing MraY inhibitors

Published:2021 Issue:26 Volume:19 Page:5844-5866
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Oliver Martin¹²³⁴^ORCID,Le Corre Laurent¹²³⁴,Poinsot Mélanie¹²³⁴,Corio Alessandra¹²³⁴,Madegard Léa¹²³⁴,Bosco Michaël¹²³⁴^ORCID,Amoroso Ana⁵⁶⁷⁸⁹,Joris Bernard⁵⁶⁷⁸⁹,Auger Rodolphe¹⁰¹¹¹²¹³¹⁴,Touzé Thierry¹⁰¹¹¹²¹³¹⁴,Bouhss Ahmed¹⁵¹⁶¹⁷¹⁸¹⁹,Calvet-Vitale Sandrine¹²³⁴^ORCID,Gravier-Pelletier Christine¹²³⁴^ORCID

Affiliation:

1. Université de Paris

2. Faculté des Sciences

3. F-75006 Paris

4. France

5. Unité de Physiologie et Génétique Bactériennes

6. Centre d'Ingénierie des Protéines

7. Département des Sciences de la Vie

8. Université de Liège

9. B4000 Liège 1

10. Institute for Integrative Biology of the Cell (I2BC)

11. CNRS

12. Université Paris Sud

13. CEA

14. Orsay

15. Laboratoire Structure-Activité des Biomolécules Normales et Pathologiques (SABNP)

16. Univ Evry

17. INSERM U1204

18. Université Paris-Saclay

19. 91025 Evry

Abstract

The synthesis and biological evaluation of a panel of 11 aminoribosyl uridines substituted by a 5′-methylene-urea are described. Molecular modeling studies were performed to rationalize their activity against the bacterial transferase MraY.

Funder

Centre National de la Recherche Scientifique

Ministère de l'Enseignement Supérieur et de la Recherche

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/OB/D1OB00710F

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