Biological gel-based microchamber array for tumor cell proliferation and migration studies in well-controlled biochemical gradients

Author:

Yao Jingru12345,Li Guoqiang12345,Jiao Yang6789ORCID,Zheng Yu6789,Liu Yanping12345ORCID,Wang Gao12345,Zhou Lianjie12345,Zhang Hongfei1045,Zhang Xianquan1045,Shuai Jianwei111213514ORCID,Fan Qihui151617185ORCID,Ye Fangfu141920515,Lou Silong21225,Chen Guo12345,Song Kena12345,Liao Yong2324252627,Liu Liyu12345ORCID

Affiliation:

1. Chongqing Key Laboratory of Soft Condensed Matter Physics and Smart Materials

2. College of Physics

3. Chongqing University

4. Chongqing 401331

5. China

6. Materials Science and Engineering

7. Arizona State University

8. Tempe

9. USA

10. Hygeia International Cancer Hospital

11. Department of Physics

12. Xiamen University

13. Xiamen 361005

14. Wenzhou Institute

15. Beijing National Laboratory for Condensed Matter Physics

16. Institute of Physics

17. Chinese Academy of Sciences

18. Beijing 100190

19. University of Chinese Academy of Sciences

20. Wenzhou

21. Chongqing University Cancer Hospital

22. Chongqing 400044

23. Institute for Viral Hepatitis

24. Department of Infectious Diseases

25. Second Affiliated Hospital

26. Chongqing Medical University

27. Chongqing 400331

Abstract

A microchamber array with composite ECM device enables the construction of a more realistic model for investigating cancer migration mechanisms and has potential to serve as a platform for personalized medicine screening.

Funder

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Chongqing Medical University

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

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