Emulation and evaluation of tumor cell combined chemotherapy in isotropic/anisotropic collagen fiber microenvironments

Author:

Zhou Lianjie1,Li Guoqiang12,Yao Jingru1,Wang Jing3ORCID,Yao Xiyao1,Ye Zhikai3,Zheng Dongtian1,Song Kena4,Zhang Hongfei5,Zhang Xianquan5,Shuai Jianwei63ORCID,Ye Fangfu73ORCID,Li Ming7ORCID,Li Yufeng8,Chen Guo1,Cheng Yuyan2,Liu He9ORCID,Shaw Peter9ORCID,Liu Liyu1ORCID

Affiliation:

1. Chongqing Key Laboratory of Soft Condensed Matter Physics and Smart Materials, College of Physics, Chongqing University, Chongqing 401331, China

2. Chongqing Key Laboratory for Resource Utilization of Heavy Metal Wastewater, Chongqing University of Arts and Sciences, Yongchuan 402160, PR China

3. Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, 325000, China

4. College of Medical Technology and Engineering, Henan University of Science and Technology, Henan 471023, China

5. Hygeia International Cancer Hospital, Chongqing 401331, China

6. Department of Physics, Xiamen University, Xiamen 361005, China

7. Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China

8. Shaanxi Provincial Key Laboratory of Photonics & Information Technology, Xi'an Jiaotong University, Xi'an 710049, China

9. Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision, and Brain Health), Wenzhou, Zhejiang 325000, China

Abstract

The microfluidic system emulating isotropic/anisotropic collagen fiber microenvironments provides a quantitative chemotherapy evaluation platform for early-stage and late-stage breast cancer.

Funder

Chongqing Municipal Education Commission

Chongqing University of Arts and Sciences

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

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