An improved methodology for the synthesis of 1α,25-dihydroxy-20-epi-vitamin D3 (MC 1288) and Gemini analog Ro-438-3582
Author:
Affiliation:
1. Departamento de Química Orgánica
2. Facultad de Química and Instituto de Investigación Sanitaria Galicia Sur (IISGS)
3. University of Vigo
4. 36310 Vigo
5. Spain
Abstract
Control over the C-20 stereochemistry allows a versatile method to introduce novel side-chains into the vitamin D scaffold.
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2017/QO/C7QO00381A
Reference11 articles.
1. An efficient synthesis of 1α,25-dihydroxy-20-epi-vitamin D3
2. Formal Desymmetrization of the Diastereotopic Chains in Gemini Calcitriol Derivatives with Two Different Side Chains at C-20
3. Gene expression profiling changes induced by a novel Gemini Vitamin D derivative during the progression of breast cancer
4. Calcitriol derivatives with two different side chains at C-20
5. Gemini Vitamin D Analogues Inhibit Estrogen Receptor–Positive and Estrogen Receptor–Negative Mammary Tumorigenesis without Hypercalcemic Toxicity
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1. Development of novel Gemini-cholesterol analogues for retinoid-related orphan receptors;Organic Chemistry Frontiers;2022
2. Crystal structure of (20S)-21-[4-(2-hydroxypropan-2-yl)-1H-1,2,3-triazol-4-yl]-20-(4-methylpentyl)-5-pregnen-3β-ol with an unknown solvate;Acta Crystallographica Section E Crystallographic Communications;2018-03-06
3. A more reliable synthesis of a Gemini vitamin D analog, a potentially effective chemotherapeutic agent for the treatment of colorectal carcinomas;Organic Chemistry Frontiers;2018
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