A more reliable synthesis of a Gemini vitamin D analog, a potentially effective chemotherapeutic agent for the treatment of colorectal carcinomas-Reference-Cited by-同舟云学术

A more reliable synthesis of a Gemini vitamin D analog, a potentially effective chemotherapeutic agent for the treatment of colorectal carcinomas

Published:2018 Issue:13 Volume:5 Page:2016-2019
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Santalla Hugo¹²³⁴⁵,Garrido Fátima¹²³⁴⁵,Gómez Generosa¹²³⁴⁵,Fall Yagamare¹²³⁴⁵^ORCID

Affiliation:

1. Departamento de Química Orgánica

2. Facultad de Química and Instituto de Investigación Sanitaria Galicia Sur (IISGS)

3. University of Vigo

4. 36310 Vigo

5. Spain

Abstract

After a serendipitous synthesis of a potentially effective chemotherapeutic agent for the treatment of colorectal carcinomas, a more reliable synthetic method is now described using our building blocks containing stereodefined stereochemistry at C-20.

Funder

Consellería de Cultura, Educación e Ordenación Universitaria, Xunta de Galicia

Universidade de Vigo

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/QO/C8QO00338F

Reference13 articles.

1. Formal Desymmetrization of the Diastereotopic Chains in Gemini Calcitriol Derivatives with Two Different Side Chains at C-20

2. Gene expression profiling changes induced by a novel Gemini Vitamin D derivative during the progression of breast cancer

3. Calcitriol derivatives with two different side chains at C-20

4. Gemini Vitamin D Analogues Inhibit Estrogen Receptor–Positive and Estrogen Receptor–Negative Mammary Tumorigenesis without Hypercalcemic Toxicity

5. Calcitriol Derivatives with Two Different Side Chains at C-20. V. Potent Inhibitors of Mammary Carcinogenesis and Inducers of Leukemia Differentiation

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