2′-N-Guanidino,4′-C-ethylene bridged thymidine (GENA-T) modified oligonucleotide exhibits triplex formation with excellent enzymatic stability-Reference-Cited by-同舟云学术

2′-N-Guanidino,4′-C-ethylene bridged thymidine (GENA-T) modified oligonucleotide exhibits triplex formation with excellent enzymatic stability

Published:2015 Issue:16 Volume:5 Page:12257-12260
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Barman Jharna¹²³⁴⁵,Gurav Deepanjali⁶⁷⁸⁹¹⁰,Oommen Oommen P.⁶⁷⁸⁹¹⁰,Varghese Oommen P.⁶⁷⁸⁹¹⁰

Affiliation:

1. Agricultural and Ecological Research Unit

2. Biological Science Division

3. Indian Statistical Institute

4. Kolkata 700108

5. India

6. Polymer Chemistry Division

7. Department of Chemistry

8. The Ångström Laboratory

9. Uppsala University

10. 751 21 Uppsala

Abstract

We present the synthesis and characterization of 2′-N-guanidino,4′-C-ethylene bridged thymidine (GENA-T) modified oligo-DNA that forms a stable triplex (ΔT_m +9.5 °C) with exceptional nuclease stability.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C4RA14721A

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