Synthesis and properties of GuNA purine/pyrimidine nucleosides and oligonucleotides
Author:
Affiliation:
1. Sohyaku. Innovative Research Division
2. Mitsubishi Tanabe Pharma Corporation
3. Aoba-ku
4. Japan
5. Graduate School of Pharmaceutical Sciences
6. Osaka University
7. Suita
8. National Institutes of Biomedical Innovation
Abstract
Facile synthesis of GuNA (guanidine-bridged nucleic acid) phosphoramidites bearing thymine, adenine, guanine, and 5-methylcytosine nucleobases and a robust method for the preparation of GuNA-modified oligonucleotides are described.
Funder
Japan Agency for Medical Research and Development
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2020/OB/D0OB01970D
Reference24 articles.
1. Advances in oligonucleotide drug delivery
2. S. T. Crooke , Antisense Drug Technology: Principles, Strategies, and Applications , CRC Press , 2nd edn, 2007 , ISBN: 0849387965
3. Antisense oligonucleotides: modifications and clinical trials
4. Guanidine bridged nucleic acid (GuNA): an effect of a cationic bridged nucleic acid on DNA binding affinity
Cited by 10 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. LncRNA MALAT1 signaling pathway and clinical applications in overcome on cancers metastasis;Clinical and Experimental Medicine;2023-09-11
2. Development of nucleic acid medicines based on chemical technology;Advanced Drug Delivery Reviews;2023-08
3. Mechanism of the extremely high duplex-forming ability of oligonucleotides modified with N-tert-butylguanidine- or N-tert-butyl-N′- methylguanidine-bridged nucleic acids;Nucleic Acids Research;2023-07-18
4. Synthesis and properties of a novel modified nucleic acid, 2′-N-methanesulfonyl-2′-amino-locked nucleic acid;Bioorganic & Medicinal Chemistry Letters;2023-05
5. Nitro-Activated Nucleobase Exchange in the Synthesis of 2′-Fluoro-2′-Deoxyribonucleosides;The Journal of Organic Chemistry;2022-06-27
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3