Highly enantioselective addition of sulfur-containing heterocycles to isatin-derived ketimines

Author:

Franc Michael1234ORCID,Urban Michal1234ORCID,Císařová Ivana5234ORCID,Veselý Jan1234ORCID

Affiliation:

1. Department of Organic Chemistry

2. Charles University

3. 12843 Prague

4. Czech Republic

5. Department of Inorganic Chemistry

Abstract

In this study, we report a highly stereoselective addition of sulfur-containing heterocyclic compounds to isatin-derived ketimines efficiently catalyzed by cinchonidine-derived bifunctional tertiary aminothiourea (1 mol%).

Funder

Grantová Agentura České Republiky

Grantová Agentura, Univerzita Karlova

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference128 articles.

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3. A. Katritzky , C.Ramsden , J.Joule and V.Zhdankin , Handbook of Heterocyclic Chemistry , Elsevier , 3rd edn, 2010

4. Bioactive Heterocycles I-VII , ed. S. Eguchi , M. T. H. Khan and N. Motohashi , Springer , 2007–2010

5. S. Pearce , The Importance of Heterocyclic Compounds in Anti-Cancer Drug Design , in Therapeutics , 2017

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