Catalytic asymmetric aldol addition reactions of 3-fluoro-indolinone derived enolates-Reference-Cited by-同舟云学术

Catalytic asymmetric aldol addition reactions of 3-fluoro-indolinone derived enolates

Published:2017 Issue:2 Volume:15 Page:311-315
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Zhang Lijun¹²³⁴⁵,Zhang Wenzhong¹²³⁴⁵,Mei Haibo¹²³⁴⁵,Han Jianlin¹²³⁴⁵,Soloshonok Vadim A.⁶⁷⁸⁹¹⁰,Pan Yi¹²³⁴⁵

Affiliation:

1. School of Chemistry and Chemical Engineering

2. State Key laboratory of Coordination Chemistry

3. Nanjing University

4. Nanjing

5. China

6. Department of Organic Chemistry I

7. Faculty of Chemistry

8. University of the Basque Country UPV/EHU

9. 20018 San Sebastián

10. Spain

Abstract

Cu(i)/bisoxazoline ligand catalyzed asymmetric aldol reactions of fluoro-indolinone derived new type tertiary enolates have been developed. This process allows the preparation of a wide range of α-fluoro-β-aryl/hetaryl/alkyl-β-hydroxy-indolin-2-one products containing C–F quaternary stereogenic centers.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/OB/C6OB02454H

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