Affiliation:
1. College of Pharmacy, Southwest Minzu University, Chengdu 610041, China
2. Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610213, China
3. University of Chinese Academy of Sciences, Beijing 100049, China
Abstract
Organic fluorides are widely used in pharmaceuticals, agrochemicals, material sciences, and other fields due to the special physical and chemical properties of fluorine atoms. The synthesis of alkyl fluorinated compounds bearing multiple contiguous stereogenic centers is the most challenging research area in synthetic chemistry and has received extensive attention from chemists. This review summarized the important research progress in the field over the past decade, including asymmetric electrophilic fluorination and the asymmetric elaboration of fluorinated substrates (such as allylic alkylation reactions, hydrofunctionalization reactions, Mannich addition reactions, Michael addition reactions, aldol addition reactions, and miscellaneous reactions), with an emphasis on synthetic methodologies, substrate scopes, and reaction mechanisms.
Funder
Southwest Minzu University Research Startup Funds