Dinuclear osmium complexes as mitochondrion-targeting antitumor photothermal agents in vivo

Author:

Wang Meng-Fan1,Deng Yu-Ang1,Li Qing-Fang1,Tang Shi-Jie1,Yang Rong1,Zhao Run-Yu1,Liu Fu-Dan1,Ren Xiaoxia2,Zhang Dan3,Gao Feng1ORCID

Affiliation:

1. Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Provincial Center for Research & Development of Natural Products, School of Pharmacy, Yunnan University, Kunming, 650091, P. R. China

2. Animal Research and Resource Center, School of Life Sciences, Yunnan University, Kunming, 650091, P. R. China

3. First Affiliated Hospital of Kunming Medical University, Kunming 650032, P. R. China

Abstract

Mitochondrion-targeting dinuclear osmium complexes with extremely high photothermal conversion capability under irradiation of an 808 nm low-power laser without nucleus affinity and photodynamic activity act as antitumor photothermal therapy agents in vivo.

Funder

National Natural Science Foundation of China

Ten Thousand Talent Plans for Young Top-notch Talents of Yunnan Province

Yunnan Provincial Science and Technology Department

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

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