Catalytic hydrogenation of functionalized amides under basic and neutral conditions

Author:

John Jeremy M.1234,Loorthuraja Rasu1567,Antoniuk Evan1567,Bergens Steven H.1567

Affiliation:

1. Department of Chemistry

2. Massachusetts Institute of Technology

3. Cambridge

4. USA

5. University of Alberta

6. Edmonton

7. Canada

Abstract

A new, base-free high turnover number (TON) catalyst for hydrogenation of simple and functionalized amides is prepared by reacting [Ru(η3-C3H5)(Ph2P(CH2)2NH2)2]BF4 and BH4 under hydrogen.

Publisher

Royal Society of Chemistry (RSC)

Subject

Catalysis

Reference38 articles.

1. P. D. Bailey , T. J.Mills, R.Pettecrew and R. A.Price, in Comprehensive Organic Functional Group Transformations II: 5.06 – Amides, ed. A. R. Katritzky and R. J. K. Taylor, Elsevier, Oxford, 2005, pp. 201–294

2. Modern Amination Methods, ed. A. Ricci, Wiley-VCH, Weinheim, 2000

3. Modern Reduction Methods, ed. P. G. Andersson and I. J. Munslow, Wiley-VCH, Weinheim, 2008

4. J. Seyden-Penne , Reductions by the Aumino- and Borohydrides in Organic Synthesis, Wiley, New York, 2nd edn, 1997

5. Highly Chemoselective Reduction of Amides (Primary, Secondary, Tertiary) to Alcohols using SmI2/Amine/H2O under Mild Conditions

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