Affiliation:
1. Platov South-Russian State Polytechnic University
2. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Abstract
AbstractA new approach for the preparation of a variety of 3-arylated 2-furoic acid derivatives has been developed. The approach involves selective Ru-catalyzed C3-H arylation of the furan moiety of readily available 2-furoyl-1-methylimidazole (using imidazole as a removable N-donor directing group), subsequent N-methylation, and nucleophilic substitution of the imidazole moiety with N, O, S, and C nucleophiles.
Funder
Russian Science Foundation