An experimental approach probing the conformational transitions and energy landscape of antibodies: a glimmer of hope for reviving lost therapeutic candidates using ionic liquid-Reference-Cited by-同舟云学术

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An experimental approach probing the conformational transitions and energy landscape of antibodies: a glimmer of hope for reviving lost therapeutic candidates using ionic liquid

Published:2021 Issue:27 Volume:12 Page:9528-9545
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Shmool Talia A.¹²³⁴^ORCID,Martin Laura K.⁵⁶⁷⁴^ORCID,Bui-Le Liem¹²³⁴^ORCID,Moya-Ramirez Ignacio¹²³⁴^ORCID,Kotidis Pavlos¹²³⁴^ORCID,Matthews Richard P.¹²³⁴^ORCID,Venter Gerhard A.⁸⁹¹⁰¹¹¹²^ORCID,Kontoravdi Cleo¹²³⁴^ORCID,Polizzi Karen M.¹²³⁴^ORCID,Hallett Jason P.¹²³⁴^ORCID

Affiliation:

1. Department of Chemical Engineering

2. Imperial College London

3. London SW7 2AZ

4. UK

5. Department of Engineering Science

6. University of Oxford

7. Oxford OX1 3PJ

8. Scientific Computing Research Unit

9. Department of Chemistry

10. University of Cape Town

11. Cape Town 7701

12. South Africa

Abstract

Probing the energy landscape and thermodynamics of biomolecules for drug design.

Funder

Engineering and Physical Sciences Research Council

Daphne Jackson Trust

Royal Society of Chemistry

Royal Academy of Engineering

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC02520A

Reference80 articles.

1. Protein Misfolding and Aggregation in Alzheimer’s Disease and Type 2 Diabetes Mellitus

2. Alzheimer's Disease and the Amyloid-β Peptide

3. Folding versus aggregation: Polypeptide conformations on competing pathways

4. Folding Free Energy Landscape of Ordered and Intrinsically Disordered Proteins

5. Comparing the energy landscapes for native folding and aggregation of PrP

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