Template directed synthesis of antibody Fc conjugates with concomitant ligand release-Reference-Cited by-同舟云学术

Template directed synthesis of antibody Fc conjugates with concomitant ligand release

Published:2022 Issue:14 Volume:13 Page:3965-3976
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Postupalenko Viktoriia¹^ORCID,Marx Léo²^ORCID,Viertl David³⁴^ORCID,Gsponer Nadège¹^ORCID,Gasilova Natalia⁵,Denoel Thibaut³^ORCID,Schaefer Niklaus³^ORCID,Prior John O.³^ORCID,Hagens Gerrit¹^ORCID,Lévy Frédéric⁶,Garrouste Patrick²,Segura Jean-Manuel¹^ORCID,Nyanguile Origène¹^ORCID

Affiliation:

1. Institute of Life Technologies, HES-SO Valais-Wallis, Rue de l'Industrie 23, CH-1950 Sion, Switzerland

2. Debiopharm Research & Manufacturing SA, Campus “après-demain”, Rue du Levant 146, 1920 Martigny, Switzerland

3. Department of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital, CH-1011 Lausanne, Switzerland

4. In Vivo Imaging Facility, Department of Research and Training, University of Lausanne, CH-1011 Lausanne, Switzerland

5. EPFL Valais Wallis, MSEAP, ISIC-GE-VS, rue de l'Industrie 17, 1951 Sion, Switzerland

6. Debiopharm International SA, Forum “après-demain”, Chemin Messidor 5-7, Case postale 5911, 1002 Lausanne, Switzerland

Abstract

A method is reported to attach a radionuclide chelator in a single step chemistry to the Fc domain of any therapeutic antibody.

Funder

Innosuisse – Schweizerische Agentur für Innovationsförderung

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D1SC06182H

Reference56 articles.

1. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries

2. Chemotherapy and the war on cancer

3. Review of precision cancer medicine: Evolution of the treatment paradigm

4. Antibody therapy of cancer

5. A 2015 update on predictive molecular pathology and its role in targeted cancer therapy: a review focussing on clinical relevance

Cited by 10 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Antibody–Drug Conjugates—Evolution and Perspectives;International Journal of Molecular Sciences;2024-06-26

2. AJICAP-M: Traceless Affinity Peptide Mediated Conjugation Technology for Site-Selective Antibody–Drug Conjugate Synthesis;Organic Letters;2024-04-19

3. Peptide‐Directed Attachment of Hydroxylamines to Specific Lysines of IgG Antibodies for Bioconjugations with Acylboronates;Angewandte Chemie International Edition;2024-03-15

4. Peptide‐Directed Attachment of Hydroxylamines to Specific Lysines of IgG Antibodies for Bioconjugations with Acylboronates;Angewandte Chemie;2024-03-15

5. A Kinetically Controlled Bioconjugation Method for the Synthesis of Radioimmunoconjugates and the Development of a Domain Mapping MS-Workflow for Its Characterization;Bioconjugate Chemistry;2024-02-17