A metal-free strategy to construct fluoroalkyl–olefin linkages using fluoroalkanes-Reference-Cited by-同舟云学术

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A metal-free strategy to construct fluoroalkyl–olefin linkages using fluoroalkanes

Published:2024 Issue:5 Volume:15 Page:1752-1757
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Chakrabarti Kaushik¹,Wade Wolfe Michael M.¹,Guo Shuo²^ORCID,Tucker Joseph W.³,Lee Jisun³^ORCID,Szymczak Nathaniel K.¹^ORCID

Affiliation:

1. Department of Chemistry, University of Michigan, 930 N. University, Ann Arbor, Michigan 48109, USA

2. College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, P.R. China

3. Medicine Design, Pfizer Inc., Eastern Point Rd, Groton, CT, 06340, USA

Abstract

We report a metal-free strategy to access fluoroalkyl–olefin linkages from RCF2H (R = aryl, H, F and fluoroalkyl) precursors and vinyl-pinacol boronic ester (BPin) reagents.

Funder

Division of Chemistry

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D3SC05616C

Reference73 articles.

1. Fluorine in Pharmaceuticals: Looking Beyond Intuition

2. Contribution of Organofluorine Compounds to Pharmaceuticals

3. Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas

4. Discovery of Ledipasvir (GS-5885): A Potent, Once-Daily Oral NS5A Inhibitor for the Treatment of Hepatitis C Virus Infection

5. Electrophilic Fluorination−Nucleophilic Addition Reaction Mediated by Selectfluor: Mechanistic Studies and New Applications

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